Bioimage informatics

QuantCenter is the framework for 3DHISTECH image analysis applications. with the goal of helping the pathologists to diagnose in an easier way. QuantCenter, is optimized for whole slide quantification. It has a linkable algorithm concept that tries to provide an easy-to-use and logical workflow. The user has different quantification modules that he or she could link one after other to fine-tune or to speed up the analysis.

ASAP is an open source platform for visualizing, annotating and automatically analyzing whole-slide histopathology images. It consists of several key-components (slide input/output, image processing, viewer) which can be used seperately. It is built on top of several well-developed open source packages like OpenSlide, Qt and OpenCV but also tries to extend them in several meaningful ways.

This package contains some MatLab tools for multi-scale image processing. Briefly, the tools include: - Recursive multi-scale image decompositions (pyramids), including Laplacian pyramids, QMFs, Wavelets, and steerable pyramids. These operate on 1D or 2D signals of arbitrary dimension. Data structures are compatible with the MatLab wavelet toolbox. - Fast 2D convolution routines, with subsampling and boundary-handling. - Fast point-operations, histograms, histogram-matching. - Fast synthetic image generation: sine gratings, zone plates, fractals, etc. - Display routines for images and pyramids. These include several auto-scaling options, rounding to integer zoom factors to avoid resampling artifacts, and useful labeling (dimensions and gray-range).

It is a trainable interest point (anatomical landmarks) detection algorithm. It requires images and interest point coordinates. It can run independantly (using csv files to describe coordinates) or it can be executed using Cytomine.

Typical application: Morphometric studies (e.g. in zebrafish/drosphila development)

Used in: Evaluation and Comparison of Anatomical Landmark Detection Methods for Cephalometric X-Ray Images: A Grand Challenge http://dx.doi.org/10.1109/TMI.2015.2412951 Automatic localization of interest points in zebrafish images with tree-based methods 

Neurolucida is a powerful tool for creating and analyzing realistic, meaningful, and quantifiable neuron reconstructions from microscope images. Perform detailed morphometric analysis of neurons, such as quantifying 1) the number of dendrites, axons, nodes, synapses, and spines, 2) the length, width, and volume of dendrites and axons, 3) the area and volume of the soma, and 4) the complexity and extension of neurons. See 10.3389/fnins.2012.00049