Type
Author
Matuszewski, D. J., Wählby, C., Puigvert, J. C., Sintorn, I.-M.
Execution Platform
Programming Language
Interaction Level
License/Openness
License
BSD-3-clause
Description

PopulationProfiler – is light-weight cross-platform open-source tool for data analysis in image-based screening experiments. The main idea is to reduce per-cell measurements to per-well distributions, each represented by a histogram. These can be optionally further reduced to sub-type counts based on gating (setting bin ranges) of known control distributions and local adjustments to histogram shape. Such analysis is necessary in a wide variety of applications, e.g. DNA damage assessment using foci intensity distributions, assessment of cell type specific markers, and cell cycle analysis.

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